MLN4924 and the Neddylation Nexus: Mechanistic Insights a...

2025-10-21

This thought-leadership article dissects the scientific and translational promise of MLN4924, a potent NEDD8-activating enzyme (NAE) inhibitor, for cancer research. Integrating the latest mechanistic findings—including glutamine metabolism rewiring via CRL3-SPOP E3 ligase inhibition—this article offers strategic guidance for translational researchers navigating the evolving landscape of neddylation pathway inhibition, cullin-RING ligase (CRL) ubiquitination disruption, and anti-cancer therapeutic development.